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Brand: Galderma S.A.
Product Code: 1-45
Availability: In Stock
Manufactured: France

Available Options


Properties and indications:

  • Differin® 0.1% cream is intended for the treatment and prevention of acne;
  • it contains a synthetic retinoid 4th generation – adapalene in the concentration of 0.1%;
  • has a powerful anti-inflammatory action and removes black spots;
  • removes dead cells from the skin surface and renews it;
  • rarely causes irritation;
  • cream for dry and sensitive skin, gel - for oily;
  • manufacturing - France;
  • big tube size - 50g/1.76oz

The composition and release form:

cream/gel for external use 50g/1.76oz

Differin Cream:

Active ingredient: adapalene 1.0 mg. Excipients: carbomer, PEG-20 methyl glucose sesquistearate, glycerol, natural squalene, methyl parahydroxybenzoate 0.2%, proryl parahydroxybenzoate 0.1%, disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide, purified water.

Differin Gel:

Active ingredient: adapalene 1.0 mg. Excipients: carbomer, propylene glycol, poloxamer 182, disodium edetate, methyl parahydroxybenzoate 0.1%, phenoxyethanol 0.25%, sodium hydroxide, purified water.


  • hypersensitivity to any component of the preparation;
  • children under 12 years;
  • pregnancy and lactation;
  • skin lesions (wounds, burns, etc.);
  • photosensitivity.


  • dermatitis;
  • eczema.

Side effects of the preparation

Perhaps the peeling and redness of the skin, if applied in large quantities.

In case of the development of irritation of the skin, treatment should be suspended until the disappearance of irritation or to reduce the frequency of application.

Dosage and how to use:

  • wash away oiliness and dirt from the skin by applying a cleanser;
  • applied once or twice daily to clean, dry skin, avoiding the eyes and lips. It can be used in the daytime;
  • if the feeling of tightness or dryness of the skin, apply a little moisturizer (but no earlier than 1 hour);
  • after the procedure is required to wash your hands;
  • therapeutic effect develops after 4-8 weeks of treatment, persistent improvement after 3 months of treatment;
  • continue to use to achieve sustainable improvements in order to avoid a repetition of rash;
  • a second course is possible after consultation with a physician.

Special instructions:

  • avoid contact with eyes and mucous membranes;
  • if accidentally contact with the drug on the mucous membranes of the eyes, mouth, or nose, rinse thoroughly with warm water;
  • may use non-comedogenic cosmetics, but the area where it was applied, should be thoroughly cleaned;
  • avoid direct sunlight, since may appear mild skin irritation;
  • having a tan, treatment should begin after the weakening of tanning;
  • do not use with products that have irritation or desiccating properties, including alcohol-based agents and formulations containing sulfur, resorcinol, salicylic acid, or (possibly increased side effects).

Interaction with other drugs

Since Differin cream doesn't react with oxygen and is not destroyed by light, it may be used with other topical and systemic treatments for acne, such as clindamycin phosphate and benzoyl peroxide.

Shelf life:

36 months

Storage conditions:

  • at a temperature not exceeding 25 °C;
  • do not freeze;
  • keep out of the reach of children.

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